{"product_id":"sigma-gentamicin-sulfate-salt-powder-bioreagent-suitable-for-cell-culture","title":"SIGMA Gentamicin sulfate salt, powder, BioReagent, suitable for cell culture","description":"\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eSIGMA Gentamicin sulfate salt, powder, BioReagent, suitable for cell culture\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSynonym(s):\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eGaramycin; Gentiomycin C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS No.:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e1405-41-0\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eApplication:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eUsed as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. Recommended for use in cell culture applications at 50 mg\/L\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGeneral description:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eGentamicin sulfate is a broad spectrum antibiotic that inhibits the growth of a wide variety of Gram-positive and Gram-negative microorganisms, including strains resistant to tetracycline, chloramphenicol, kanamycin, and colistin; particularly strains of Pseudomonas, Proteus, Staphylococcus, and Streptococcus. Gentamicin sulfate inhibits bacterial protein biosynthesis by binding to the 30S subunit of the ribosome.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e2-8°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEC No.:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e215-778-9\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBiochem\/physiol Actions:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eMode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.\u003csup\u003e1,\u003c\/sup\u003e\u003csup\u003e2\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eThe bactericidal effect of gentamicin on\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ePseudomonas aeruginosa\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eis exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.\u003csup\u003e3\u003c\/sup\u003e\u003cbr\u003eAntimicrobial spectrum: Gram-negative bacteria,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eStaphylococcus aureus\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eand other Gram-positive bacteria\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEmpirical Formula (Hill Notation):\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eC\u003csub\u003e4\u003c\/sub\u003eHCl\u003csub\u003e3\u003c\/sub\u003eN\u003csub\u003e2\u003c\/sub\u003e\u003c\/p\u003e","brand":"Sigma-Millipore","offers":[{"title":"50MG","offer_id":44192995049626,"sku":"G1264-50MG","price":35.7,"currency_code":"USD","in_stock":true},{"title":"250MG","offer_id":44192995082394,"sku":"G1264-250MG","price":69.23,"currency_code":"USD","in_stock":true},{"title":"1g","offer_id":44192995115162,"sku":"G1264-1G","price":189.21,"currency_code":"USD","in_stock":true},{"title":"5g","offer_id":44192995147930,"sku":"G1264-5G","price":629.23,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/5025\/3722\/products\/SIGMA.gif?v=1701801426","url":"https:\/\/animal.ivfstore.com\/es\/products\/sigma-gentamicin-sulfate-salt-powder-bioreagent-suitable-for-cell-culture","provider":"Animal IVF Store","version":"1.0","type":"link"}