{"product_id":"cbs-high-security-tubes","title":"CBS High Security Tubes","description":"\u003ch2\u003eCBS High Security Tubes\u003c\/h2\u003e\n\u003cp\u003eThe unique fully secured system for storage in liquid nitrogen.\u003c\/p\u003e\n\u003cp\u003eThese are the optimum devices are the perfect replacement for Cryo Vials for semen and ovarian tissue freezing under liquid nitrogen. Available in a box of 20 individually wrapped, or a box of 50.\u003c\/p\u003e\n\u003cp\u003eCBS High Security tubes are derived from the CBS high security concept designed for optimum sample preservation. Made of biocompatible resin, CBS tubes eliminate concerns related to cross-contamination and issues induced by storage in liquid nitrogen.\u003c\/p\u003e\n\u003cp\u003eOnce sealed with the \u003ca href=\"https:\/\/us.ivfstore.com\/products\/syms-iii-sealer-for-cbs-high-security-straws-tubes-and-vitrification-straws\" title=\"SYMSIII CBS High Security Straw and Tube Sealer\"\u003eSYMS III sealer\u003c\/a\u003e, the CBS High Security tube will be placed in storage boxes and in current storage systems. The tubes can be opened with either special scissors or the \u003ca href=\"https:\/\/us.ivfstore.com\/collections\/new-products\/products\/syso-automatic-cbs-high-security-tube-opening-device\"\u003eSYSO automatic opening device.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eThe CBS High Security tube is CE marked and has Class II\/a medical device certification; offering the opportunity for use in clinical phases and for therapeutic purposes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSafety\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFull seals eliminate risks of cross-contamination of the sample and its environment.\u003c\/li\u003e\n\u003cli\u003eValidated as leak-proof and shatter-proof in all cryogenic temperatures including temperatures as low as liquid nitrogen phase.\u003c\/li\u003e\n\u003cli\u003eIndestructible under normal conditions of use.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eTraceability options\u003c\/strong\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eColored inserts for simple identification in cryogenic environments\u003c\/li\u003e\n\u003cli\u003e2D data matrix coded inserts\u003c\/li\u003e\n\u003cli\u003eCompatible with cryoresistant labels.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eCompatibility\u003c\/strong\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStandard racks, boxes (9x9 or 10x10), canes\u003c\/li\u003e\n\u003cli\u003eManual or automatic filling systems\u003c\/li\u003e\n\u003cli\u003eProgrammable freezers\u003c\/li\u003e\n\u003cli\u003eCryogenic storage conditions for use in liquid nitrogen, vapor phase, mechanical freezers\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eFields of application\u003c\/strong\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePreservation of fertility (ovarian and testicular tissue, and sperm) for Assisted Reproductive Technologies\u003c\/li\u003e\n\u003cli\u003eBiological tissue banks for clinical phase or research\u003c\/li\u003e\n\u003cli\u003eBlood banks and blood transfusion centers\u003c\/li\u003e\n\u003cli\u003eCell and genetic therapy (clinical phase and therapeutic applications)\u003c\/li\u003e\n\u003cli\u003ePackaging of vaccines and heat-sensitive drugs\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eCharacteristics\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eUsable working volume: 1.2mL\u003c\/li\u003e\n\u003cli\u003eDimensions: 48 mm, Ø 11.8 mm\u003c\/li\u003e\n\u003cli\u003eService temperature: from + 40°C to cryogenic temperature -196°C\u003c\/li\u003e\n\u003cli\u003eLiquid nitrogen and vapor phase validated\u003c\/li\u003e\n\u003cli\u003e2D data matrix capacity: 10 digits\u003c\/li\u003e\n\u003cli\u003e2D data matrix symbol size: 12 x 12 (rows x columns).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2245\/7875\/files\/Flyer-CBS_Tube.pdf?v=1733944192\" data-mce-href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2245\/7875\/files\/Flyer-CBS_Tube.pdf?v=1733944192\"\u003eFlyer\u003c\/a\u003e\u003cbr\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2245\/7875\/files\/CBS_High_Security_Tubes_validation_studies.pdf?v=1733944192\" data-mce-href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2245\/7875\/files\/CBS_High_Security_Tubes_validation_studies.pdf?v=1733944192\"\u003eValidation Studies\u003c\/a\u003e\u003cbr\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2245\/7875\/files\/Validation_of_CBS_Tube_for_cell_lines_-_IZSLER.pdf?v=1733944194\"\u003eValidation Study Details\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ciframe title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/vDWywK-5a88?si=5wiqWx-YS75q6_4e\" height=\"315\" width=\"560\" allowfullscreen=\"\" referrerpolicy=\"strict-origin-when-cross-origin\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ciframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/x-2qhUK8nc8?si=V2CUkjYFo5tqYuKd\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSpecifications\u003c\/b\u003e\u003c\/p\u003e\n\u003ctable width=\"100%\" style=\"width: 100.098832%; height: 37.647056px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 18.823528px;\"\u003e\n\u003ctd style=\"width: 34.064318%; height: 18.823528px;\"\u003eSKU 022252\u003c\/td\u003e\n\u003ctd style=\"width: 64.935105%; height: 18.823528px;\"\u003eCBS High Security Tubes. Box of 20. Individually wrapped.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 18.823528px;\"\u003e\n\u003ctd style=\"width: 34.064318%; height: 18.823528px;\"\u003eSKU 023722\u003c\/td\u003e\n\u003ctd style=\"width: 64.935105%; height: 18.823528px;\"\u003eCBS High Security Tubes. Box of 50.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCBS™ High Security Tubes are produced under \u003c\/b\u003e\u003cb\u003eGMP and ISO 7 conditions.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCryo Bio System is ISO 13485 certified.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eA complete testing program has been realized to validate the use of CBS™ High Security Tubes for cryopreservation of biological samples.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eQUALITY ASSURANCE\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eSterile CBS™ High Security tubes have been tested on:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003e\u003c\/span\u003eEndotoxin by LAL methodology (\u0026lt;1 EU\/unit)\u003c\/li\u003e\n\u003cli\u003eOne cell Mouse Embryo Assay (\u0026gt;80% expanded to blastocysts in 96h)\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003eSterilization by irradiation to a Sterility Assurance Level (SAL) of 10(-6)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAll results are reported on a lot specific ‘Certificate of analysis’, which is available upon request\u003cspan\u003e\u003cb\u003e.\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePRODUCT VALIDATION\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCBS™ High Security Tubes made from virgin grade ionomeric resin have been\u003c\/p\u003e\n\u003cp\u003evalidated on:\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eCell Toxicity\u003c\/span\u003e: No difference in cell survival and development between CBS™ High Security Tubes and standard cryogenic vials\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: Three cell lines (MRC 5, BXPC3 and CCRF-CEM) pipetted at room temperature, \u003c\/i\u003e\u003ci\u003esealed, frozen, stored under liquid nitrogen and thawed in CBS™ High Security Tubes and \u003c\/i\u003e\u003ci\u003ein standard cryogenic vials. Laboratory: IZSLER, Italy\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eDNAses and RNases\u003c\/span\u003e : Product is free of detectable DNases and RNases\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: CBS™ High Security tubes are successively vortex washed with 200 µl DEPC \u003c\/i\u003e\u003ci\u003ewater. RNA and DNA standards are incubated 1h at 37°C and 5 min at 65°C with \u003c\/i\u003e\u003ci\u003eextraction fluid (that has been in contact with sample Y\/N) and then quantified for \u003c\/i\u003e\u003ci\u003ecomparison. Laboratory: Mo Bio, USA\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003ePyrogenicity\u003c\/span\u003e: Pyrogen free\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: In vivo pyrogen test USP\u0026lt;151\u0026gt; and Pharm Eur 2.6.8.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eExtractables\u003c\/span\u003e:\u003c\/p\u003e\n\u003cp\u003eBisphenol A: No detectable level of Bisphenol A\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: Analysis by HPLC – UV acetonitrile extract, 5h ultrasound, room \u003c\/i\u003e\u003ci\u003etemperature. Laboratory Intertek, France\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003eParabenes: No detectable levels of methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: Analysis by HPLC-UV of (mixtures of) extraction solvents: acetonitrile, \u003c\/i\u003e\u003ci\u003emethanol, methanol-acetonitrile, THF-methanol, acetonitrile) after 5 + 5 hours \u003c\/i\u003e\u003ci\u003eultrasound. Laboratory Intertek, France\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003ePhtalates: No detectable levels of DMP, DIHxP, DPP, DNHP, BBP, DBEP,\u003c\/p\u003e\n\u003cp\u003eDnOP, DNP, DMEP, DINP, DIDP. No quantifiable levels of DEP, DBP, DIBP,\u003c\/p\u003e\n\u003cp\u003eDEHP and DCHP\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: GC-MS analyses of two toluene extracts (5 hours ultrasound. Laboratory \u003c\/i\u003e\u003ci\u003eIntertek, France\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003eNo other carcinogen\/mutagen\/reproductive toxic components detected\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eLeachables\u003c\/span\u003e: Based on the absence or very low concentrations of extractables, no leachables studies have been done\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eCell Cryopreservation\u003c\/span\u003e: No difference in cell survival and development over 6 days between CBS™ High Security Tubes and standard cryogenic vials\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: Three cell lines (MRC 5, BXPC3 and CCRF-CEM) pipetted, sealed, CRF frozen (-\u003c\/i\u003e\u003ci\u003e1°C\/min from +5°C till -40°C, -10°C\/min from -40°C till -70°C and immersion in LN2) and \u003c\/i\u003e\u003ci\u003e37°C water bath thawed in new CBS and in standard ST vials . Replication and \u003c\/i\u003e\u003ci\u003edevelopment counted for 6 days. Laboratory: IZSLER, Italy\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eCross contamination in the sealing process\u003c\/span\u003e: No cross contamination was detected between highly contaminated and non-contaminated CBS™ High Security Tubes successively sealed with the same SYMS II sealer\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: Two cell lines (PK15cl 28\/BS, MDBK) contaminated or not with mycoplasma \u003c\/i\u003e\u003ci\u003eorale and bovine entero virus in CBS™ High Security Tubes and in standard cryogenic \u003c\/i\u003e\u003ci\u003evials for controls . Real-time PCR for detection of mycoplasma DNA. Virus infection \u003c\/i\u003e\u003ci\u003edetection by isolation technologies\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eCross contamination in liquid nitrogen storage\u003c\/span\u003e: No cross contamination was detected between highly contaminated and non-contaminated CBS™ High Security Tubes immerged for 3 weeks in the same liquid nitrogen vessel.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: Two cell lines (PK15cl 28\/BS, MDBK) contaminated or not with mycoplasma \u003c\/i\u003e\u003ci\u003eorale and bovine entero virus in CBS™ High Security Tubes and in standard cryogenic \u003c\/i\u003e\u003ci\u003evials for controls. Real-time PCR for detection of mycoplasma DNA. Virus infection \u003c\/i\u003e\u003ci\u003edetection by isolation technologies\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003eResistance to immersion and storage in liquid nitrogen: No break after direct immersion in liquid nitrogen followed by storage under liquid nitrogen\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtocol: CBS™ High Security Tubes filled with 1 ml of water at room temperature are \u003c\/i\u003e\u003ci\u003ethermally sealed and immediately immerged in liquid nitrogen and stored for 48 hours.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eTubes are pressure tested for leakage after warming.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eResistance to centrifugation forces\u003c\/span\u003e: No break or leaks at 3000 G for 10 minutes at 22°C\u003c\/p\u003e","brand":"Cryo Bio System","offers":[{"title":"Box of 20 Individually Packed","offer_id":51887909667182,"sku":"022252","price":58.0,"currency_code":"USD","in_stock":true},{"title":"Box of 50","offer_id":51887909699950,"sku":"023722","price":106.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/5025\/3722\/files\/CBStubeprimary.jpg?v=1741098087","url":"https:\/\/animal.ivfstore.com\/es\/products\/cbs-high-security-tubes","provider":"Animal IVF Store","version":"1.0","type":"link"}